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Doxy-PEP (doxycycline post-exposure prophylaxis) is a preventive treatment involving the antibiotic doxycycline, which is taken after potential exposure to sexually transmitted infections (STIs) to reduce the risk of acquiring infections like syphilis, chlamydia, and gonorrhea.

Doxy-PEP reduces your chance of acquiring syphilis, gonorrhea, and chlamydia by over 70% when taken within 24 hours and no later than 72 hours.

You should take Doxy-PEP (doxycycline post-exposure prophylaxis) as soon as possible after a potential exposure to a sexually transmitted infection (STI), ideally within 72 hours (3 days). The earlier you take it after exposure, the more effective it will be in preventing infections like syphilis, chlamydia, and gonorrhea.

PrEP (Pre-exposure Prophylaxis) and Doxy-PEP (Doxycycline Post-Exposure Prophylaxis) are both methods used to reduce the risk of sexually transmitted infections (STIs), but they serve different purposes and target different infections. Here’s a breakdown of the key differences:

• PrEP:
  • Prevention before exposure.
  • PrEP is a medication (typically Truvada or Descovy) taken before potential exposure to prevent HIV. It is highly effective in reducing the risk of HIV transmission when taken as prescribed.

     

• Doxy-PEP:
  • Prevention after exposure.
  • Doxy-PEP is a doxycycline antibiotic taken after a potential exposure to prevent bacterial STIs, such as syphilis, chlamydia, and gonorrhea.

Doxy-PEP (doxycycline post-exposure prophylaxis) generally has a similar side effect profile to regular doxycycline, as it involves using this antibiotic to prevent certain bacterial STIs (such as syphilis, chlamydia, and gonorrhea). While many people tolerate doxycycline well, there are some potential side effects to be aware of.

Common Side Effects:

1. Gastrointestinal Issues:
   • Nausea
   • Upset stomach
   • Vomiting
   • Diarrhea
   • Loss of appetite

These side effects are relatively common but are often mild. Taking doxycycline with food or a full glass of water can help reduce these symptoms.

2. Skin Reactions:
   • Sun sensitivity: Doxycycline can increase sensitivity to sunlight, leading to an increased risk of sunburn. It’s important to use sunscreen and avoid excessive sun exposure.
   • Rash: Skin rashes can occur in some people, though they are not as common.
3. Headache:
   • Some people may experience mild headaches while taking doxycycline.
4. Esophageal Irritation or Ulcers:
   • Taking doxycycline without enough water or lying down shortly after taking the pill can increase the risk of esophageal irritation or ulcers.